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human leukemia cell lines karpas 299  (DSMZ)


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    DSMZ human leukemia cell lines karpas 299
    Human Leukemia Cell Lines Karpas 299, supplied by DSMZ, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human leukemia cell lines karpas 299/product/DSMZ
    Average 90 stars, based on 1 article reviews
    human leukemia cell lines karpas 299 - by Bioz Stars, 2026-03
    90/100 stars

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    karpas 299  (ATCC)
    93
    ATCC karpas 299
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Karpas 299, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    karpas 299 - by Bioz Stars, 2026-03
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    299 homemade n a oligonucleotides btn2a1 qpcr primer pair sino biological cat  (Sino Biological)
    94
    Sino Biological 299 homemade n a oligonucleotides btn2a1 qpcr primer pair sino biological cat
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    299 Homemade N A Oligonucleotides Btn2a1 Qpcr Primer Pair Sino Biological Cat, supplied by Sino Biological, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/299 homemade n a oligonucleotides btn2a1 qpcr primer pair sino biological cat/product/Sino Biological
    Average 94 stars, based on 1 article reviews
    299 homemade n a oligonucleotides btn2a1 qpcr primer pair sino biological cat - by Bioz Stars, 2026-03
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    human leukemia cell lines karpas 299  (DSMZ)
    90
    DSMZ human leukemia cell lines karpas 299
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Human Leukemia Cell Lines Karpas 299, supplied by DSMZ, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human leukemia cell lines karpas 299/product/DSMZ
    Average 90 stars, based on 1 article reviews
    human leukemia cell lines karpas 299 - by Bioz Stars, 2026-03
    90/100 stars
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    karpas-299 cells  (European Collection of Authenticated Cell Cultures)
    90
    European Collection of Authenticated Cell Cultures karpas-299 cells
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Karpas 299 Cells, supplied by European Collection of Authenticated Cell Cultures, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/karpas-299 cells/product/European Collection of Authenticated Cell Cultures
    Average 90 stars, based on 1 article reviews
    karpas-299 cells - by Bioz Stars, 2026-03
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    karpas-299 cell line  (DSMZ)
    90
    DSMZ karpas-299 cell line
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Karpas 299 Cell Line, supplied by DSMZ, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/karpas-299 cell line/product/DSMZ
    Average 90 stars, based on 1 article reviews
    karpas-299 cell line - by Bioz Stars, 2026-03
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    human t-cell lymphoma line karpas 299  (European Collection of Authenticated Cell Cultures)
    90
    European Collection of Authenticated Cell Cultures human t-cell lymphoma line karpas 299
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Human T Cell Lymphoma Line Karpas 299, supplied by European Collection of Authenticated Cell Cultures, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human t-cell lymphoma line karpas 299/product/European Collection of Authenticated Cell Cultures
    Average 90 stars, based on 1 article reviews
    human t-cell lymphoma line karpas 299 - by Bioz Stars, 2026-03
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    karpas-299 cells  (Charles River Laboratories)
    90
    Charles River Laboratories karpas-299 cells
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Karpas 299 Cells, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/karpas-299 cells/product/Charles River Laboratories
    Average 90 stars, based on 1 article reviews
    karpas-299 cells - by Bioz Stars, 2026-03
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    karpas-299 cells  (Janvier Labs)
    90
    Janvier Labs karpas-299 cells
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Karpas 299 Cells, supplied by Janvier Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/karpas-299 cells/product/Janvier Labs
    Average 90 stars, based on 1 article reviews
    karpas-299 cells - by Bioz Stars, 2026-03
    90/100 stars
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    karpas 299 cells  (DSMZ)
    90
    DSMZ karpas 299 cells
    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) <t>and</t> <t>Karpas-299</t> cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .
    Karpas 299 Cells, supplied by DSMZ, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/karpas 299 cells/product/DSMZ
    Average 90 stars, based on 1 article reviews
    karpas 299 cells - by Bioz Stars, 2026-03
    90/100 stars
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    karpas 299 k299  (DSMZ)
    94
    DSMZ karpas 299 k299
    Figure 2. CD47 surface expression after exposure to TKIs in sensitive and off-target resistant ALK- positive cell lines. (A–F) CD47 surface expression, analyzed using flow cytometry, in lymphoma cell line <t>K299,</t> AS4 cell line, lung cancer cell line H3122 (sensitive to alectinib and resistant to lorlatinib) and neuroblastoma cell line CLB-Ga-LR1000, according to TKIs used; two-way ANOVA with multiple comparisons correction, K299 F(1,32) = 12.29, AS4CRIZO F(1,8) = 52.08, AS4LORLA F(1,8) = 182.8, H3122 F(1,7) = 348.5, H3122LORLA F(1,8) = 24.54; experimental triplicates; ns: not significant; * p < 0.05, ** p < 0.01, **** p < 0.0001; for CLB-Ga-LR1000: unpaired, one-tailed Student’s t-test, * p < 0.05).
    Karpas 299 K299, supplied by DSMZ, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/karpas 299 k299/product/DSMZ
    Average 94 stars, based on 1 article reviews
    karpas 299 k299 - by Bioz Stars, 2026-03
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    a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) and Karpas-299 cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .

    Journal: Nature Communications

    Article Title: Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates

    doi: 10.1038/s41467-026-68605-y

    Figure Lengend Snippet: a DAR8 ADCs from trastuzumab (tras/anti-HER2, red), datopotamab (Dato/anti-Trop2, green) or brentuximab (bren/anti-CD30, blue) in combination with linker 9 for aromatic (highlighted with pink background) and linker 15 for aliphatic payloads (highlighted with purple background). b Ganetespib and ON01300 have been conjugated via linker 9 ; BAY-2402234, DHODH-IN-16, SNX2112, paclitaxel and LSN3154567 have been conjugated via linker 15 . Pink shading refers to aromatic payloads, purple shading refers to primary aliphatic payloads, blue shading refers to secondary aliphatic payloads and green shading refers to tertriary aliphatic payloads. c HIC chromatograms to analyze ADC homogeneity from every payload. A DAR of 8 has been confirmed by MS. d Potency and selectivity of the different ADCs for the targeted cell line. Tras-ADCs were tested on N87 (red solid circle), SKBR-3 (red solid downward-pointing triangle) and HCC1569 (red solid upward-pointing triangle) (HER2 + ), bren-ADCs were tested on L-540 (blue half-filled circles) and Karpas-299 cells (blue half-filled diamonds) (CD30 + ), dato-ADCs were tested on H441 (green open circles), MDA-MB-468 (green open diamonds) and HCC-78-cells (green open squares) (Trop2 + ), while the bren conjugates served as isotypes for the HER2+ and Trop2 + -cell lines and vice versa. The ADC selectivity is plotted as the ratio of IC 50 isotype-/IC 50 targeted ADC. The absolute potencies of the ADCs are plotted for their target-positive cell lines. Pink columns refer to aromatic payloads, purple columns refer to primary aliphatic payloads, blue columns refer to secondary aliphatic payloads and green columns refer to tertiary aliphatic payloads. The black bars show the mean values for the eight cell lines (targeted via three distinct receptor-antibody-pairs) and serve as orientation to compare the different payloads. e Correlation between the proliferation inhibition IC 50 of unconjugated payloads (x-axis) over the ADCs on the same cell line (y-axis) (N87, red solid circle; SKBR-3 red solid downward-pointing triangle; HCC1569, red solid upward-pointing triangle; L-540, blue half-filled circles; Karpas-299, blue half-filled diamonds; (CD30 + ); H441, green open circles; MDA-MB-468, green open diamonds; HCC-78-cells, green open squares). ADCs above the dotted line were inactive at the highest tested concentration of 80 nM and excluded from the correlation. Dose-response curves for ADCs and payloads are shown in Fig. .

    Article Snippet: Cell lines were purchased from the “German Collection of Microorganisms and Cell Cultures” (DSMZ, Leibniz Institute, Germany), American Type Culture Collection (ATCC, USA), Japanese Collection of Research Bioresources (JCRB) via Tebubio (France), Merck (Germany) or Thermo Fisher Scientific (USA): SR-786 (ACC 369, DSMZ; RRID:CVCL_1711; sex: male), L-540 (ACC 72, DSMZ; RRID:CVCL_1362; sex: female), Karpas-299 (Merck, RRID:CVCL_1324); sex: male), NCI-N87 (CRL-5822, ATCC; RRID:CVCL_1603; sex: male), SK-BR-3 (ACC 736, DSMZ; RRID:CVCL_0033; sex: female), HCC-1569 (CRL-2330, ATCC; RRID:CVCL_1255; sex: female), H441 (HTB-174, ATCC; RRID:CVCL_1561; sex: male), MDA-MB-468 (ACC 738, DSMZ; RRID:CVCL_0419; sex: female), HCC78 (ACC 563, DSMZ; RRID:CVCL_2061; sex: male), SW620 (300466, Tebubio; RRID:CVCL_0547; sex: male), ExpiCHO-S (A29127, Thermo Fisher Scientific; RRID:CVCL_5J31; sex: female).

    Techniques: Inhibition, Concentration Assay

    Figure 2. CD47 surface expression after exposure to TKIs in sensitive and off-target resistant ALK- positive cell lines. (A–F) CD47 surface expression, analyzed using flow cytometry, in lymphoma cell line K299, AS4 cell line, lung cancer cell line H3122 (sensitive to alectinib and resistant to lorlatinib) and neuroblastoma cell line CLB-Ga-LR1000, according to TKIs used; two-way ANOVA with multiple comparisons correction, K299 F(1,32) = 12.29, AS4CRIZO F(1,8) = 52.08, AS4LORLA F(1,8) = 182.8, H3122 F(1,7) = 348.5, H3122LORLA F(1,8) = 24.54; experimental triplicates; ns: not significant; * p < 0.05, ** p < 0.01, **** p < 0.0001; for CLB-Ga-LR1000: unpaired, one-tailed Student’s t-test, * p < 0.05).

    Journal: Biomedicines

    Article Title: Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies

    doi: 10.3390/biomedicines12122819

    Figure Lengend Snippet: Figure 2. CD47 surface expression after exposure to TKIs in sensitive and off-target resistant ALK- positive cell lines. (A–F) CD47 surface expression, analyzed using flow cytometry, in lymphoma cell line K299, AS4 cell line, lung cancer cell line H3122 (sensitive to alectinib and resistant to lorlatinib) and neuroblastoma cell line CLB-Ga-LR1000, according to TKIs used; two-way ANOVA with multiple comparisons correction, K299 F(1,32) = 12.29, AS4CRIZO F(1,8) = 52.08, AS4LORLA F(1,8) = 182.8, H3122 F(1,7) = 348.5, H3122LORLA F(1,8) = 24.54; experimental triplicates; ns: not significant; * p < 0.05, ** p < 0.01, **** p < 0.0001; for CLB-Ga-LR1000: unpaired, one-tailed Student’s t-test, * p < 0.05).

    Article Snippet: Karpas-299 (K299) and SUP-M2 cell lines were purchased from DSMZ (Braunschweig, Germany).

    Techniques: Expressing, Flow Cytometry, One-tailed Test

    Figure 3. Extended analysis of increased phagocytosis in a panel of ALK-positive tumor cell lines, treated with anti-CD47 mAb, previously exposed to ALKi. (A,B) Histogram analysis of phagocytic rate in ALK-positive lymphoma sensitive (K299, SUP-M2) and resistant (AS4) setting, previously exposed to crizotinib or lorlatinib, treated with anti-CD47 mAb (A); crizo- tinib 0.5 µM, lorlatinib 0.1 µM). (C) Histogram analysis of phagocytic rate in off-target re- sistant ALK-driven solid cancer cell lines (H3122-LR100, CLB-Ga-LR1000. One-way ANOVA with multiple comparisons correction; K299CRIZO F(3,8) = 34.39, K299LORLA F(3,8) = 49.50, SUP- M2CRIZO F(3,8) = 3.932, SUP-M2LORLA F(3,8) = 12.16, AS4CRIZO F(3,8) = 8.794, AS4LORLA F(3,8) = 9.344, H3122-LR100LORLA F(3,8) = 17.07; CLB-Ga-LR1000LORLA F(2,6) = 102.2; experimental triplicates, n = 3 donors; ns: not significant; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).

    Journal: Biomedicines

    Article Title: Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies

    doi: 10.3390/biomedicines12122819

    Figure Lengend Snippet: Figure 3. Extended analysis of increased phagocytosis in a panel of ALK-positive tumor cell lines, treated with anti-CD47 mAb, previously exposed to ALKi. (A,B) Histogram analysis of phagocytic rate in ALK-positive lymphoma sensitive (K299, SUP-M2) and resistant (AS4) setting, previously exposed to crizotinib or lorlatinib, treated with anti-CD47 mAb (A); crizo- tinib 0.5 µM, lorlatinib 0.1 µM). (C) Histogram analysis of phagocytic rate in off-target re- sistant ALK-driven solid cancer cell lines (H3122-LR100, CLB-Ga-LR1000. One-way ANOVA with multiple comparisons correction; K299CRIZO F(3,8) = 34.39, K299LORLA F(3,8) = 49.50, SUP- M2CRIZO F(3,8) = 3.932, SUP-M2LORLA F(3,8) = 12.16, AS4CRIZO F(3,8) = 8.794, AS4LORLA F(3,8) = 9.344, H3122-LR100LORLA F(3,8) = 17.07; CLB-Ga-LR1000LORLA F(2,6) = 102.2; experimental triplicates, n = 3 donors; ns: not significant; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).

    Article Snippet: Karpas-299 (K299) and SUP-M2 cell lines were purchased from DSMZ (Braunschweig, Germany).

    Techniques: